Advanced Immunopeptidomics at ImmuneSpec

Immunopeptidomics, also known as MAPPs (MHC-associated peptide proteomics), enables the identification of peptides that are naturally processed and presented by MHC complexes on the cell surface. If immune cells recognize these peptides as non-self, an immune response will be evoked. 

IMMUNESPEC

Advanced immunopeptidomics platform

ImmuneSpec is an advanced immunopeptidomics platform that enables high-throughput, semi-automated identification of MHC-associated peptides from biological samples while maintaining highest sensitivity. MHC complexes are purified with their bound immune peptides from cells or tissues by affinity chromatography. Peptides which were presented are then eluted and identified by mass spectrometry (LC-MS/MS). ImmuneSpec’s expertise is based on proprietary protocols and combines high-outcome purification of immune peptides, the use of ultrasensitive mass spectrometry and extensive data analysis and interpretation for maximized immune peptide identifications. 

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When Quality meets Quantity – It’s a numbers game 

At the forefront of immunopeptidomics innovation, our platform delivers maximized peptide identification with unmatched sensitivity, pushing the boundaries of immunopeptidomics. With a high-throughput, semi-automated workflow, we provide fast, precise, and reliable results. 

What Sets Us Apart? 

Small Sample Volumes

Gain comprehensive insights from small sample volumes, preserving valuable material without compromising accuracy. Our platform requires less input material (whether cells, tissue, or biotherapeutics) making immunopeptidomics accessible even for limited or precious samples.

Unmatched sensitivity

Our proprietary optimized purification protocols, combined with cutting-edge mass spectrometry and advanced data analysis, enable the detection of a maximized number of immunopeptides, delivering the most detailed and complete immunopeptide repertoire available today. 

High-Throughput Efficiency

Experience up to 2× faster turnaround times than the industry standard, thanks to our semi-automated platform designed for maximum speed and scalability.  

Maximized coverage of the full repertoire of MHC-associated peptides in a sample

Our proprietary protocols are optimized to maximize the solubilization of MHC complexes without losing bound peptides, ensuring the highest recovery rates through the use of abundant, high-quality reagents and antibodies. By prioritizing both quantity and quality, we enable fast and efficient processing without compromise. This approach also allows for sequential affinity purification from the same starting material, facilitating precise isolation of both MHC class I (HLA-A/B/C) and MHC class II complexes (HLA-DR/DP/DQ), as well as specific HLA allotypes, delivering unparalleled depth in immunopeptidomics analysis.

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Technology

Immunogenicity testing-MAPPs

Target discovery & validation

Construct validation